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KMID : 0984920080100010010
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Journal of Skin Barrier Research
2008 Volume.10 No. 1 p.10 ~ p.17
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Protease and skin barrier function
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Jeong Se-Kyoo
Park Byeong-Deog
Lee Seung-Hun
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Abstract
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Proteins are one of the most important constituents comprising the living organisms, and proteases, as their degrading enzymes, are crucial enzymes for survival of organisms. For a long time, it had been considered that proteases have only one function, degradation of proteins. However, since the first identification of thrombin receptor, which is known as protease-activated receptor (PAR)-1, the signaling activity of proteases received great deal of attention. Skin, as an outermost organ for human body, plays an important protective role, and very diverse proteases and its inhibitors are known to be expressed in this skin. Classical role of protease in human skin is mainly related to the maintenance of structural integrity and desquamation. Recent finding about the epidermal expression of PAR-2, a subclass of Gprotein coupled receptor, however, triggered the extensive research for investigating the signaling role of PAR-2 in skin. Previously, we and other research groups reported that PAR-2 in involved in the epidermal permeability barrier homeostasis, and activation of PAR-2 in skin significantly impeded barrier recovery process. It was also shown that increased activation of PAR-2 is observed in disease skin, such as atopic dermatitis. As a result, therapeutic potential
for PAR-2 specific antagonist for various skin diseases are suggested. In this review, proteases and their inhibitors in skin and their roles, especially in barrier function homeostasis, are briefly discussed, mainly focusing on PAR-2 in skin.
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KEYWORD
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epidermal permeability barrier function, protease, protease-activated receptor-2, skin
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